反应详情

According to general procedure B (R)-ethoxy-(2-fluoro-4-methoxy-phenyl)-acetic acid was reacted with [amino-(4-aminomethyl-phenyl)-methylene]-carbamic acid benzyl ester hydrochloride 1:2 (prepared according to Ch. Lila, Ph. Gloanec, L. Cadet, Y. Hervé, J. Fournier, F. Leborgne, T. J. Verbeuren, G. De Nanteuil, Synthetic Communications 1998, 28, 23, 4419–4429) to give [1-amino-1-(4-{[(R)-2-ethoxy-2-(2-fluoro-4-methoxy-phenyl)-acetylamino]-methyl}-phenyl)-meth-(E)-ylidene]-carbamic acid benzyl ester (96.5% ee). Off-white solid.