反应详情

A solution of Example 106B (1.05 g, 4.3 mmol) in pyridine (3 mL) was treated with acetic anhydride (0.82 mL, 8.6 mmol), stirred at room temperature for 2 hours, and partitioned between ethyl acetate and 2N HCl. The organic phase was washed sequentially with aqueous NaHCO3, water, and brine, dried (MgSO4), filtered, and concentrated to give 1.19 g (97% yield) of the desired product. MS (ESI(+)) m/e 304, 306 (M+H)+.

1. custompartitioned between ethyl acetate and 2N HCl
2. washThe organic phase was washed sequentially with aqueous NaHCO3, water, and brine
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated