HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1H-Isoindol-1-one, 4-bromo-2,3-dihydro-7-methoxy-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Bromo-7-hydroxyisoindolin-1-one | HCID 21907553 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1H-Isoindol-1-one, 4-bromo-2,3-dihydro-7-methoxy- | HCID 21907555 | 70% |
Reaction Steps
A solution of Example 106D (103 mg, 0.45 mmol) in DMF (4 mL) was treated with Cs2CO3 (162 mg, 0.5 mmol) and methyl iodide (0.03 mL, 0.48 mmol), stirred at room temperature for 3 hours, then poured into water. The resulting precipitate was filtered to give 76 mg (70%) of the desired product. MS (ESI(+)) m/e 242,244 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129260B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-26983ef7633a4dfd8fe5b31dd29a466a |
| Source note | uspto-grants-2006_10 |