反应详情

温度

-78 °C

Methyl[(tert-butoxycarbonyl)amino](dimethoxyphosphoryl)acetate (1.33 g, 4.46 mmol) was dissolved in dry THF (20 mL) and cooled to −78° C. under nitrogen. Tetramethylguanidine (490 mg, 4.26 mmol) was added and the solution stirred at −78° C. for a further 10 mins. A solution of 3-nitropyridine-2-carbaldehyde (Tetrahedron vol 0.54 (1998) p 6311) (618 mg, 4.06 mmol) in dry THF (5 mL.) was added drop wise. After stirring the solution for 2 hours. at −78° C. (50 mL) it was diluted with water (150 mL) and extracted with ethyl acetate. The combined extracts were washed with water (2×20 mL) and brine (20 mL), dried (MgSO4) and evaporated under reduced pressure to give a yellow oil, which was purified by column chromatography (DCM) to give the title compound as a 4:1 mixture of Z/E isomers (1.1 g, 84%).

1. stirringAfter stirring the solution for 2 hours
2. extractionextracted with ethyl acetate
3. washThe combined extracts were washed with water (2×20 mL) and brine (20 mL)
4. dry with materialdried (MgSO4)
5. customevaporated under reduced pressure
6. customto give a yellow oil, which
7. customwas purified by column chromatography (DCM)