HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(2-Chlorophenyl)cyclopropanecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,2-Dibromopropane | HCID 6553 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (o-Chlorophenyl)acetonitrile | HCID 76112 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-Chlorophenyl)cyclopropanecarbonitrile | HCID 10313355 | — |
Reaction Steps
A solution of 13.1 g of 2-chlorophenylacetonitrile and 20.3 g of 1,2-dibromopropane in 142 ml of DMF is mixed with 9 g of sodium hydride (55–65% in oil] at room temperature. It is stirred for several hours and carefully added to water. After extraction with ethyl acetate and filtration by silica gel, the desired product is obtained: 13.1 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129270B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-3d57ed97828e4b4097238383b3bc0d4e |
| Source note | uspto-grants-2006_10 |