反应详情

A suspension of N-(1-adamantylmethyl)-5-chloro-2-iodoisonicotinamide (Example2(i)) (0.43 g) and tert-butyl prop-2-ynylcarbamate, (0.31 g) in anhydrous acetonitrile (5 ml) and triethylamine (5 ml) was purged with nitrogen for 5 minutes and the copper (I) iodide (0.004 g) and bis-triphenyphosphine palladium dichloride (0.014 g) were added. The mixture was stirred under nitrogen for 0.75 hours. The mixture was concentrated and the residue was purified by chromatography on silica gel eluting with acetone:dichloromethane (1:19) to afford the sub-titled compound (0.34 g) as a yellow foam.

1. customwas purged with nitrogen for 5 minutes
2. additionthe copper (I) iodide (0.004 g) and bis-triphenyphosphine palladium dichloride (0.014 g) were added
3. concentrationThe mixture was concentrated
4. customthe residue was purified by chromatography on silica gel eluting with acetone:dichloromethane (1:19)