Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Tert-butyl 3-(4-{[(1-adamantylmethyl)amino]-carbonyl}-5-chloropyridin-2-yl)prop-2-ynyl(ethyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | tert-butyl N-ethyl-N-(prop-2-yn-1-yl)carbamate | HCID 18366151 | — |
| 반응물 | N-(1-adamantylmethyl)-5-chloro-2-iodoisonicotinamide | HCID 21906675 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Tert-butyl 3-(4-{[(1-adamantylmethyl)amino]-carbonyl}-5-chloropyridin-2-yl)prop-2-ynyl(ethyl)carbamate | HCID 21906729 | 66.5% |
반응 단계
The sub-titled compound was prepared from N-(1 adamantylmethyl)-5-chloro-2-iodoisonicotinamide (Example 2(i)) (0.40 g), tert-butyl ethyl(prop-2-ynyl)carbamate (Example 7(i)) (0.34 g), copper (I) iodide (0.004 g), bis-triphenyphosphine palladium dichloride (0.014 g), triethylamine (5 ml) and anhydrous acetonitrile (5 ml) by the method of Example 2(iii). The crude product was purified by chromatography on silica gel eluting with iso-hexane:ethyl acetate (9:1 to 7:3) to afford the sub-titled compound (0.30 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07129246B2 |
| 출처 데이터셋 | uspto-grants-2006_10 |
| ORD ID | ord-6d8ec4b762d2485e9095644448ce1180 |
| 출처 메모 | uspto-grants-2006_10 |