Hydrochloric Acid → HCID 21906700, compound

Participants

Reaction Steps

N-(1-adamantylmethyl)-2-({3-[bis(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)amino]-propyl}amino)3-chloroisonicotinamide (Example 36(iii)) in methanol (5 ml) was treated with HCl in 1,4-dioxane (3 ml). The mixture was stirred at room temperature for 3 hrs. The solvent was evaporated. The product was purified by reverse phase HPLC, using NH3/H2O/CH3CN as eluant. The resulting oil in methanol was treated with ethereal HCl and the solvent was evaporated to yield the title compound as a white solid (0.14 g).

Provenance & Evidence