HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → [5-(1-Chloro-ethyl)-2-methylsulfanyl-pyrimidin-4-yl]-methyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(4-Methylamino-2-methylsulfanyl-pyrimidin-5-yl)-ethanol | HCID 21908978 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | [5-(1-Chloro-ethyl)-2-methylsulfanyl-pyrimidin-4-yl]-methyl-amine | HCID 21908981 | 113.5% |
Reaction Steps
0.25 g of the product from Example 11a, supra, were dissolved in 10 mL chloroform and 0.30 g thionyl chloride were added drop-wise. The mixture was refluxed for 2 hrs and evaporated to yield 0.31 g of the title product as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129351B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-5cdb65d067d94eadbb9b99aa0cff1d18 |
| Source note | uspto-grants-2006_10 |