Hydrochloric Acid → HCID 11753934, compound

Participants

Reaction Conditions

Reaction Steps

{4-[3,3-Bis-(4-chloro-phenyl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid methyl ester (100 mg, 0.218 mmol) was dissolved in ethanol (10 ml). 1N NaOH (3 ml, 3 mmol) was added at room temperature and the reaction mixture was stirred for 18 h at 5° C. after which it was treated with 1N HCl (3 ml) and extracted with dichloromethane (2×20 ml). The combined organic phases were dried and evapotated to give the title compound in 50 mg (10%) yield.

Provenance & Evidence