Hydrochloric Acid → HCID 10030747, compound

Participants

Reaction Conditions

Reaction Steps

{4-[3,3-Bis-(4-bromo-phenyl)-allylsulfanyl]-2-ethyl-phenoxy}-acetic acid methyl ester (350 mg, 0.6 mmol, example 21) was dissolved in ethanol (10 ml). 1N NaOH (3 ml, 3 mmol) was added at room temperature and the reaction mixture was stirred for 18 h at 5° C. after which it was treated with 1N HCl (15 ml) and extracted with dichloromethane (2×20 ml). The combined organic phases were dried and evaporated to give the title compound in 130 mg (68%) yield.

Provenance & Evidence