HCID 68575677, compound → HCID 21907955, compound

HRID 1247682Notes

Reaction equation

HRID 1247682 reaction equation
C([O:3][C:4](=[O:32])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([S:13][CH2:14][CH:15]=[C:16]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[CH:9][C:8]=1[Cl:31])C>[OH-].[Na+].C(O)C>[Cl:23][C:20]1[CH:19]=[CH:18][C:17]([C:16]([C:24]2[CH:25]=[CH:26][C:27]([Cl:30])=[CH:28][CH:29]=2)=[CH:15][CH2:14][S:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:32])=[O:3])=[C:8]([Cl:31])[CH:9]=2)=[CH:22][CH:21]=1

Participants

4

Reactant 1

HCID 68575677HCID 68575677, compound

Product 1

HCID 21907955HCID 21907955, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of {{4-[3,3-bis-(4-chloro-phenyl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid ethyl ester (100 mg, 0.2 mmol) in 1N NaOH (1 ml) and ethanol (10 ml) was stirred at room temperature for 18 hours. The reaxtion mixture was evaporated and the residue dissolved in water (5 ml) and 1 N HCl (1.2 ml). The aquous phase was extracted with ethyl acetate (3×15 ml), dried (MgSO4) and evaporated to give the title compound in 95 mg (100%) yield.

Workup

  1. customThe reaxtion mixture was evaporated
  2. dissolutionthe residue dissolved in water (5 ml)
  3. extractionThe aquous phase was extracted with ethyl acetate (3×15 ml)
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-c53be2f9f9c64d2eb6b141ff89dcd055
Source dataset
uspto-grants-2006_10
Patent number
US07129268B2

Reaction notes

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