HCID 68577218, compound → HCID 10324141, compound

HRID 1247683Notes

Reaction equation

HRID 1247683 reaction equation
C([O:3][C:4](=[O:35])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([S:13][CH2:14][CH:15]=[C:16]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[CH:9][C:8]=1[C:31]([F:34])([F:33])[F:32])C>[OH-].[Na+].C(O)C>[Cl:30][C:27]1[CH:26]=[CH:25][C:24]([C:16]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[CH:15][CH2:14][S:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:35])=[O:3])=[C:8]([C:31]([F:34])([F:32])[F:33])[CH:9]=2)=[CH:29][CH:28]=1

Participants

4

Reactant 1

HCID 68577218HCID 68577218, compound

Product 1

HCID 10324141HCID 10324141, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of {{4-[3,3-bis-(4-chloro-phenyl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic acid ethyl ester (135 mg, 0.25 mmol) in 1N NaOH (1 ml) and ethanol (10 ml) was stirred at room temperature for 18 hours. The reaxtion mixture was evaporated and the residue dissolved in water (5 ml) and 1 N HCl (1.2 ml). The aquous phase was extracted with ethyl acetate (3×15 ml), dried (MgSO4) and evaporated to give the title compound in 130 mg (100%) yield.

Workup

  1. customThe reaxtion mixture was evaporated
  2. dissolutionthe residue dissolved in water (5 ml)
  3. extractionThe aquous phase was extracted with ethyl acetate (3×15 ml)
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-58b60ff87e9a42a1a0c90937882e7909
Source dataset
uspto-grants-2006_10
Patent number
US07129268B2

Reaction notes

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