{4-[3,3-Bis-(3-methyl-thiophen-2-yl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic acid ethyl ester → HCID 10096846, compound

HRID 1247686Notes

Reaction equation

HRID 1247686 reaction equation
C([O:3][C:4](=[O:33])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([S:13][CH2:14][CH:15]=[C:16]([C:23]2[S:24][CH:25]=[CH:26][C:27]=2[CH3:28])[C:17]2[S:18][CH:19]=[CH:20][C:21]=2[CH3:22])=[CH:9][C:8]=1[C:29]([F:32])([F:31])[F:30])C>[OH-].[Na+].C(O)C>[CH3:22][C:21]1[CH:20]=[CH:19][S:18][C:17]=1[C:16]([C:23]1[S:24][CH:25]=[CH:26][C:27]=1[CH3:28])=[CH:15][CH2:14][S:13][C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:33])=[O:3])=[C:8]([C:29]([F:31])([F:32])[F:30])[CH:9]=1

Participants

4

Reactant 1

HCID 68575646{4-[3,3-Bis-(3-methyl-thiophen-2-yl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic acid ethyl ester

Product 1

HCID 10096846HCID 10096846, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of {4-[3,3-bis-(3-methyl-thiophen-2-yl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic acid ethyl ester (75 mg, 0.15 mmol) in 1N NaOH (0.02 ml) and ethanol (10 ml) was stirred at room temperature for 2 hours. The reaxtion mixture was evaporated and the residue dissolved in 1 N HCl (0.03 ml). The aquous phase was extracted with methylene choride (3×25 ml), dried (MgSO4) and evaporated to give the title compound in 70 mg (99%) yield.

Workup

  1. customThe reaxtion mixture was evaporated
  2. dissolutionthe residue dissolved in 1 N HCl (0.03 ml)
  3. extractionThe aquous phase was extracted with methylene choride (3×25 ml)
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-2b157da0cd8d44a3a44a79b593d15cec
Source dataset
uspto-grants-2006_10
Patent number
US07129268B2

Reaction notes

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