反应详情

A solution of {4-[3,3-bis-(3-methyl-thiophen-2-yl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic acid ethyl ester (75 mg, 0.15 mmol) in 1N NaOH (0.02 ml) and ethanol (10 ml) was stirred at room temperature for 2 hours. The reaxtion mixture was evaporated and the residue dissolved in 1 N HCl (0.03 ml). The aquous phase was extracted with methylene choride (3×25 ml), dried (MgSO4) and evaporated to give the title compound in 70 mg (99%) yield.

1. customThe reaxtion mixture was evaporated
2. dissolutionthe residue dissolved in 1 N HCl (0.03 ml)
3. extractionThe aquous phase was extracted with methylene choride (3×25 ml)
4. dry with materialdried (MgSO4)
5. customevaporated