Sodium Hydroxide → HCID 10366216, compound

HRID 1247692Notes

Reaction equation

HRID 1247692 reaction equation
C([O:3][C:4](=[O:31])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([S:13][CH2:14][CH:15]=[C:16]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>C(O)C>[Cl:30][C:27]1[CH:26]=[CH:25][C:24]([C:16]([C:17]2[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=2)=[CH:15][CH2:14][S:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:31])=[O:3])=[CH:8][CH:9]=2)=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68575120HCID 68575120, compound

Product 1

HCID 10366216HCID 10366216, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

{4-[3,3-Bis-(4-chlorophenyl)-allylsulfanyl]-phenoxy}-acetic acid ethyl ester (130 mg, 0.27 mmol) was dissolved in warm ethanol (10 ml). 1N NaOH (1 ml) was added at room temperature and the reaction mixture was stirred for 18 h after which it was evaporated. The residue was treated with 1N HCl (1.2 ml) and extracted with ethyl acetate (3×25 ml). The combined organic phases were dried and evaporated to give the title compound in 48 mg (38%) yield.

Workup

  1. customwas evaporated
  2. additionThe residue was treated with 1N HCl (1.2 ml)
  3. extractionextracted with ethyl acetate (3×25 ml)
  4. customThe combined organic phases were dried
  5. customevaporated

Sources & evidence

ORD record
ord-923fd3bbd084484680b93b2dd8be7390
Source dataset
uspto-grants-2006_10
Patent number
US07129268B2

Reaction notes

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