Methanol → HCID 86596485, compound

HRID 1247696Notes

Reaction equation

[CH3:1][OH:2].[S:3](=[O:7])(=[O:6])([OH:5])[OH:4].[CH:8]([Cl:11])([Cl:10])[Cl:9]>>[CH:8]([Cl:11])([Cl:10])[Cl:9].[CH3:1][OH:2].[S:3](=[O:5])(=[O:4])([OH:7])[OH:6]

Participants

Reactant 3

HCID 887Methanol

HCID 1118Sulfuric Acid

HCID 6212Chloroform

Product 1

HCID 86596485HCID 86596485, compound

Procedure

A colorless solid (yield: 91.0%) was obtained through reaction conducted as in example 54 except that the reactants were replaced by the compound (123) prepared in example 23 (0.5 g), methanol (42.7 mL), chloroform (42.7 mL) and sulfuric acid (36 N, 0.26 mL), the reaction temperature was lowered to room temperature, and the reaction time was extended to 72 hours. 1H-NMR data showed that the product consisted of a compound (144) and the compound (123) (content of compound (144): 81.5 mol %).

Workup

customwas lowered to room temperature

Sources & evidence

ORD record: ord-db5c3e024d714186bdf1d5560617a3a9
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129370B2

Reaction notes

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