反应详情

To a suspension of 2,4-dihydroxybenzaldehyde (0.83 g) and cesium carbonate (1.7 g) in acetonitrile (30 mL) was added chloromethyl methyl ether (0.55 mL), and the mixture was stirred at room temperature for 30 minutes. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gal (eluent: hexane/ethyl acetate=4/1) to give 2-hydroxy-4-(methoxymethyloxy)benzaldehyde (0.84 g).

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. customthe solvent was removed under reduced pressure
4. customThe residue was purified by column chromatography on silica gal (eluent: hexane/ethyl acetate=4/1)