Potassium Nitrate → 7-nitro-2,3-dihydro-1H-imidazo[1,2-b]pyrazole

HRID 1247776Notes

Reaction equation

HRID 1247776 reaction equation
[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][CH:7]=2)[CH2:3][CH2:2]1.[N+:9]([O-])([O-:11])=[O:10].[K+]>S(=O)(=O)(O)O>[N+:9]([C:7]1[CH:6]=[N:5][N:4]2[CH2:3][CH2:2][NH:1][C:8]=12)([O-:11])=[O:10]

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 2424712,3-Dihydro-1H-imidazo(1,2-b)pyrazole

Product 1

HCID 1358007277-nitro-2,3-dihydro-1H-imidazo[1,2-b]pyrazoleYield 78%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To a solution of 2,3-dihydro-1H-imidazo[1,2-b]pyrazole (120 g) in sulfuric acid (500 ml) was added potassium nitrate (111 g) under ice-cooling. The mixture was stirred at room temperature for 48 hours. The reaction mixture was added to ice (2.0 kg). The crystalline residue was collected by filtration and dried in vacuo to give 7-nitro-2,3-dihydro-1H-imidazo[1,2-b]pyrazole (132 g) as a solid.

Workup

  1. temperaturecooling
  2. filtrationThe crystalline residue was collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e455c9826d524ddf830cac9834758c97
Source dataset
uspto-grants-2006_10
Patent number
US07129232B2

Reaction notes

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