Sulfuric Acid → 2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-amine sulfate

HRID 1247777Notes

Reaction equation

HRID 1247777 reaction equation
[N+:1]([C:4]1[CH:8]=[N:7][N:6]2[CH2:9][CH2:10][NH:11][C:5]=12)([O-])=O.[S:12](=[O:16])(=[O:15])([OH:14])[OH:13]>[Pd].O>[S:12](=[O:14])(=[O:13])([OH:16])[OH:15].[NH2:1][C:4]1[CH:8]=[N:7][N:6]2[CH2:9][CH2:10][NH:11][C:5]=12

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 1358007277-nitro-2,3-dihydro-1H-imidazo[1,2-b]pyrazole

Product 1

HCID 1358007252,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-amine sulfate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A suspension of 7-nitro-2,3-dihydro-1H-imidazo[1,2-b]pyrazole (97 g) in a mixed solvent of sulfuric acid (34 ml) and water (2000 ml) was treated with 10% palladium on carbon (10 g) under a hydrogen atmosphere at room temperature for 4 days. After the catalyst was filtered off, the filtrate was concentrated in vacuo. The residue was triturated with methanol and dried in vacuo to give 7-amino-2,3-dihydro-1H-imidazo[1,2-b]pyrazole sulfuric acid salt (90.2 g) as a solid.

Workup

  1. filtrationAfter the catalyst was filtered off
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was triturated with methanol
  4. customdried in vacuo

Sources & evidence

ORD record
ord-0475053b0c904eeaa989765f29a36aa7
Source dataset
uspto-grants-2006_10
Patent number
US07129232B2

Reaction notes

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