Diethyl Ether → tert-butyl 2-[(2-([1-methyl-5-(tritylamino)-1H-pyrazol-4-yl]amino}-3,4-dioxocyclobut-1-en-1-yl)amino]ethylcarbamate

Participants

Reaction Steps

To a suspension of tert-butyl 2-aminoethylcarbamate (288 mg) and 3-ethoxy-4-{[1-methyl-5-(tritylamino)-1H-pyrazol-4-yl]amino}-3-cyclobutene-1,2-dione (718 mg) in ethanol (20 ml) was added triethylamine (0.209 ml), and the mixture was stirred under reflux for 4 hours. To the reaction mixture were added diethyl ether and hexane. The crystalline precipitate was collected by filtration and dried in vacuo to give tert-butyl 2-[(2-{[1-methyl-5-(tritylamino)-1H-pyrazol-4-yl]amino}-3,4-dioxocyclobut-1-en-1-yl)amino]ethylcarbamate (830 mg) as a solid.

Provenance & Evidence