Diisopropyl Ether → HCID 21904559, compound

Participants

Reaction Steps

To a solution of 1-(2-fluoroethyl)-1H-pyrazol-5-amine (12 g) in ethanol (30 ml) were added concentrated hydrochloric acid (70 mg) and isoamyl nitrite (10.9 g). The reaction mixture was stirred at 25–38° C. for 2 hours. Diisopropyl ether and hexane were added to the reaction mixture, and the resulting oil was purified by column chromatography on silica gel (ethyl acetate:hexane=1:2→1:1→2:1→1:0) to give-1-(2-fluoroethyl)-4-nitroso-1H-pyrazol-5-amine (4.8 g).

Provenance & Evidence