Hydrazine hydrate (1:1) → HCID 13475879, compound

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Reaction Steps

A mixture of 1-methyl-γ-oxo-2-phenyl-1H-imidazole-4-butanoic acid and of 1-methyl-γ-oxo-2-phenyl-1H-imidazole-5-butanoic acid (as obtained by method B, ca 60:40 ratio) in 150 ml of ethanol and 25 ml of glacial acetic acid is treated with 12 ml of hydrazine hydrate at 85° C. for six hours and then is allowed to stand overnight at room temperature. The solid is collected, washed with water, then with cold ethanol, and finally with ether giving 4.2 g of pure 4,5-dihydro-6-(1-methyl-2-phenyl-1H-imidazol-4-yl)-3(2H)-pyridazinone as nearly white crystals, mp 271°-272° C., dec.

Provenance & Evidence