5-[(6-Methylpyridin-3-yl)methyl]-2-(methylsulfanyl)pyrimidin-4(3H)-one → HCID 178424600, compound

HRID 1247897Notes

Reaction equation

HRID 1247897 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]2[C:10](=[O:17])[NH:11][C:12](SC)=[N:13][CH:14]=2)=[CH:4][CH:3]=1.[NH:18]([C:22]1[S:23][CH:24]=[C:25]([CH2:27][S:28][CH2:29][CH2:30][NH2:31])[N:26]=1)[C:19]([NH2:21])=[NH:20]>N1C=CC=CC=1>[NH:18]([C:22]1[S:23][CH:24]=[C:25]([CH2:27][S:28][CH2:29][CH2:30][NH:31][C:12]2[NH:11][C:10](=[O:17])[C:9]([CH2:8][C:5]3[CH:6]=[N:7][C:2]([CH3:1])=[CH:3][CH:4]=3)=[CH:14][N:13]=2)[N:26]=1)[C:19]([NH2:21])=[NH:20]

Participants

4

Reactant 2

HCID 127838275-[(6-Methylpyridin-3-yl)methyl]-2-(methylsulfanyl)pyrimidin-4(3H)-oneHCID 1785127232-[4-(2-Aminoethylsulfanylmethyl)-1,3-thiazol-2-yl]guanidine

Product 1

HCID 178424600HCID 178424600, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Equimolar amounts of 5-(6-methyl-3-pyridylmethyl)-2-methylthio-4-pyrimidone and 2-(2-guanidino-4-thiazolylmethylthio)ethylamine are refluxed together with pyridine for 48 hours to give 2-[2-(2-guanidino-4-thiazolylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

Sources & evidence

ORD record
ord-a99a0bc9e5f347dba2801a9ad57dc7c4
Source dataset
uspto-grants-1985_06
Patent number
US04521418

Reaction notes

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