2,6-Difluorobenzoyl isocyanate → HCID 13472357, compound

HRID 1247907Notes

Reaction equation

HRID 1247907 reaction equation
[C:1]1([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][N:13]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[F:19][C:20]1[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[C:21]=1[C:22]([N:24]=[C:25]=[O:26])=[O:23]>C1(C)C=CC=CC=1>[C:1]1([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:25]([NH:24][C:22](=[O:23])[C:21]3[C:27]([F:31])=[CH:28][CH:29]=[CH:30][C:20]=3[F:19])=[O:26])=[CH:14][N:13]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 27333692,6-Difluorobenzoyl isocyanateHCID 13472356HCID 13472356, compound

Product 1

HCID 13472357HCID 13472357, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A mixture of 2.5 g. of 2-(1-naphthoxy)-5-amino pyridine and 8.13 ml. of toluene was heated up to 50° C. To this resulting homgeneous solution was added a solution of 3.1 g. of 2,6-difluorobenzoyl isocyanate in 2 ml. of toluene. The resulting mixture was heated at 80° for 1.5 hours, cooled, and filtered to give 4.7 g. of white crystals; mp. 223.5°-224.0°.

Workup

  1. additionA mixture of 2.5 g
  2. additionTo this resulting homgeneous solution was added a solution of 3.1 g
  3. temperatureThe resulting mixture was heated at 80° for 1.5 hours
  4. temperaturecooled
  5. filtrationfiltered
  6. customto give 4.7 g

Sources & evidence

ORD record
ord-36d35a59b21f42d19772ad3f836baa12
Source dataset
uspto-grants-1985_06
Patent number
US04521426

Reaction notes

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