Hydrochloric Acid → Zantac

Participants

Reaction Steps

One equivalent (about 5.3 ml) of concentrated hydrochloride acid was added to a solution of ranitidine (20 g) in a mixture of propan-2-ol (130 ml) and water (4 ml) at 45°. The mixture was heated at 50° whilst a further quantity of propan-2-ol (68 ml) was added and the resulting solution was then stirred at 50° to allow the product to crystallise. The slurry was cooled to 10° to 12° and the product was filtered off, washed with propan-2-ol (2×27 ml) and dried at 50° under reduced pressure to give Form 2 ranitidine hydrochloride (21 g) m.p. 139°-141°.

Provenance & Evidence