Hydrochloric Acid → Zantac

Participants

Reaction Steps

Ranitidine (6 g) was dissolved in industrial methylated spirits (42 ml) at ambient temperature (about 20°). One equivalent (about 1.6 ml) of concentrated hydrochloric acid was added to the solution. The temperature rose to about 27° and the solution was seeded at this temperature to induce crystallisation. The product crystallised to give a thick slurry at 25°-27°. After 0.5 h the slurry was cooled to 10°-12° for 0.5 h. The product was then filtered off, washed with industrial methylated spirits (5 ml) and dried at 50° under reduced pressure to give Form 2 ranitidine hydrochloride (5.4 g) m.p. 139°-140°.

Provenance & Evidence