Tetrahydrofuran → HCID 20280071, compound

Participants

Reaction Steps

A mixture of 3-[N-(2-formyloxyethyl)formamido]-pyridine (7.01 g) and sodium bicarbonate (3.04 g) in a mixed solution of tetrahydrofuran (60 ml) and water (110 ml) was stirred for 8 hours at 45° to 46° C. The reaction mixture was extracted with a mixed solvent of chloroform and ethanol (1:1) and the extract was evaporated. The residue was dissolved in a mixed solvent of chloroform and ethanol (4:1) and subjected to column chromatography on silica gel (150 g). The elution was carried out with the same solvent and the fractions containing an object compound were collected and evaporated to give 3-[N-(2-hydroxyethyl)formamido]pyridine (4.60 g) as an oil.

Provenance & Evidence