Hydrochloric Acid → HCID 54357234, compound

Participants

Reaction Steps

3-(3-ethoxy-benzylidene)-1,2,3,10-tetrahydro-10-oxo-cyclopenta[d]pyrido[1,2-a]pyrimidine-7-carboxylic acid (2.7 g), prepared according to Example 4, was heated with 37% HCl (54 ml) in acetic acid (54 ml) under stirring at reflux temperature for 20 hours. After cooling the precipitate was filtered, washed with water and then treated with aqueous sodium acetate under stirring: filtration and crystallization of the precipitate from dimethylformamide gave 1.85 g of 3-(3-hydroxy-benzylidene)-1,2,3,10-tetrahydro-10-oxo-cyclopenta[d]pyrido[1,2-a]pyrimidine-7-carboxylic acid, m.p. >320° C.

Provenance & Evidence