Triethylamine → HCID 70381148, compound

Participants

Reaction Steps

1.04 g of (+)-cis-2-(4-ethoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-1,5-benzothiazepin-4(5H)-one are dissolved in 20 ml of anhydrous benzene, and 1 ml of triethylamine is added thereto. A solution of 0.62 g of 2-chloro-4-nitrobenzoyl chloride in 2 ml of anhydrous benzene is added to the mixture under stirring, and said mixture is stirred at room temperature for 0.5 hour. After the reaction, the mixture is washed with water, dried and condensed to dryness. The residue is recrystallized from ethanol, whereby 0.94 g of (+)-cis-2-(4-ethoxyphenyl)-3-(2-chloro-4-nitrobenzoyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-1,5-benzothiazepin-4(5H)-one is obtained as pale yellow needles. Yield: 61%.

Provenance & Evidence