Potassium Carbonate → (+)-cis-2-(4-methoxyphenyl)-3-(2-chloro-4-nitrobenzoyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Participants

Reaction Steps

970 mg of (-)-cis-2-(4-methoxyphenyl)-3-(2-chloro-4-nitrobenzoyloxy)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one are dissolved in 15 ml of acetone, and 690 mg of potassium carbonate and 375 mg of 2-(dimethylamino)ethyl chloride hydrochloride are added thereto. The mixture is refluxed for 6 hours under stirring. After the reaction, the mixture is evaporated under reduced pressure to remove solvent. Ethyl acetate is added to the residue, and the mixture is washed with water. The ethyl acetate solution is dried and evaporated under reduced pressure to remove solvent. The residue is dissolved in ethanol under heating, and the mixture is allowed to stand. Crystalline precipitates are collected by filtration and dried, whereby 810 mg of (+)-cis-2-(4-methoxyphenyl)-3-(2-chloro-4-nitrobenzoyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-1,5-benzothiazepin-4(5H)-one are obtained as pale yellow needles. Yield: 73%.

Provenance & Evidence