HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-[2-(6-Methyl-2-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pyridine, 2-(2-chloroethyl)-6-methyl-, hydrochloride (1:1) | HCID 205443 | — |
| Reactant | 4-[3-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine | HCID 11128034 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[2-(6-Methyl-2-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride | HCID 20280526 | 36.4% |
Reaction Steps
By operating as described in Example 1, 5.7 g of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine are reacted with 5.2 g of 2-(2-chloroethyl)-6-methylpyridine hydrochloride in the presence of 7.5 ml of triethylamine in 60 ml of ethanol at reflux for 18 hours to obtain 3.5 g of 1-[2-(6-methyl-2-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride; m.p. 207°-210° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04521428 |
| Source dataset | uspto-grants-1985_06 |
| ORD ID | ord-606ee38013914c88b06d16a834d9d509 |
| Source note | uspto-grants-1985_06 |