Dichloroacetyl chloride → HCID 13125056, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 8 g (0.2 mole) of sodium hydroxide in 15 ml of water was added to a solution of 20 g (0.18 mole) of 2-methyl-piperazin-3-one in 150 ml of methylene chloride. 26.6 g (0.18 mole) of dichloroacetyl chloride were then added dropwise at from 10° to 15° C. The mixture was stirred at 25° C. for 10 hours and the precipitated crude product was filtered off with suction, washed with water and recrystallized from a 2:1 mixture of isopropanol and H2O to give 14.4 g (36% theory) of 1-dichloroacetyl-2-methyl-3-oxo-piperazine of melting point 167°-168° C.

Provenance & Evidence