4-(Pyrrolidin-3-yl)pyridine → 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-[3-(4-pyridinyl)-1-pyrrolidinyl]-1,8-naphthyridine-3-carboxylic acid

HRID 124805Notes

Reaction equation

HRID 124805 reaction equation
[Cl:1][c:2]1[c:3]([F:24])[cH:4][c:5]2[c:6](=[O:23])[c:7]([C:20](=[O:21])[OH:22])[cH:8][n:9](-[c:12]3[c:13]([F:19])[cH:14][c:15]([F:18])[cH:16][cH:17]3)[c:10]2[n:11]1.[NH:25]1[CH2:26][CH:27]([c:30]2[cH:31][cH:32][n:33][cH:34][cH:35]2)[CH2:28][CH2:29]1>>[c:2]1([N:25]2[CH2:26][CH:27]([c:30]3[cH:31][cH:32][n:33][cH:34][cH:35]3)[CH2:28][CH2:29]2)[c:3]([F:24])[cH:4][c:5]2[c:6](=[O:23])[c:7]([C:20](=[O:21])[OH:22])[cH:8][n:9](-[c:12]3[c:13]([F:19])[cH:14][c:15]([F:18])[cH:16][cH:17]3)[c:10]2[n:11]1

Participants

3

Reactant 2

HCID 49931054-(Pyrrolidin-3-yl)pyridineHCID 105460847-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Product 1

HCID 152312971-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-[3-(4-pyridinyl)-1-pyrrolidinyl]-1,8-naphthyridine-3-carboxylic acid

Sources & evidence

ORD record
ord-d85b75d927e041208c728a7610edacc1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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