HCID 12851922, compound → HCID 20280794, compound

Participants

Reaction Steps

N-(3-Acetylthio-2-methylpropionyl)-N-(5,6-dimethoxy-1-indanyl)glycine (1.0 g) is dissolved in 50 ml of 5.5N methanolic ammonia, and the mixture is stirred at room temperature for 2 hours. The reaction mixture is concentrated at 40° C. under reduced pressure, and the residue is dissolved in 10 ml of water, made acidic with 10% hydrochloric acid, and extracted with 200 ml of ethyl acetate. The extract is washed with water, dried, and then treated with activated carbon. After ethyl acetate is distilled off under reduced pressure, a mixture of ethyl ether and petroleum ether is added to the residue to give 6.6 g of N-(3-mercapto-2-methylpropionyl)-N-(5,6-dimethoxy-1-indanyl)glycine as colorless powder.

Provenance & Evidence