HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-oxovalerate → Methyl 2-propionyl-4-[4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy]-3-oxopentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-oxovalerate | HCID 121699 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 13389070 | HCID 13389070 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Methyl 2-propionyl-4-[4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy]-3-oxopentanoate | HCID 20278409 | — |
Reaction Steps
Following the procedure of Example 4, 2-[4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy]propionic acid chloride is added to the sodium salt of methyl propionylacetate in benzene to give methyl 2-propionyl-4-[4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy]-3-oxopentanoate (cpd. 27, Table C). This pentanoate is then heated with sodium chloride and DMSO to give 2-[4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy]-3,5-heptanedione (cpd. 27, Table D).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04522647 |
| Source dataset | uspto-grants-1985_06 |
| ORD ID | ord-f828e5c886544595a05e1637760a3184 |
| Source note | uspto-grants-1985_06 |