Ethyl Acetoacetate → HCID 86740148, compound

Participants

Reaction Steps

Following the above procedures, (R)-2-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]propionic acid chloride, prepared from (R)-2-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]propionic acid and thionyl chloride, is reacted with the sodium salt of ethyl acetoacetate to give ethyl (R)-2-acetyl-4-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]-3-oxopentanoate (XVIII: Q1 is N, Y is hydrogen, Z is trifluoromethyl and R3 is ethyl). This pentanoate is then heated with sodium chloride to give (R)-5-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]2,4-hexanedione (XIX; Q1 is N, Y is hydrogen and Z is trifluoromethyl).

Provenance & Evidence