HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetoacetate → HCID 86740150, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 12905973 | HCID 12905973 | — |
| Reactant | (2R)-2-{4-[4-(Trifluoromethyl)phenoxy]phenoxy}propanoyl chloride | HCID 12906016 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 86740150 | HCID 86740150 | — |
Reaction Steps
Following the procedure of Example 12, (R)-2-[4-(4-trifluoromethylphenoxy)phenoxy]propionic acid chloride is prepared from (R)-2-[4-(4-trifluoromethylphenoxy)phenoxy]propionic acid (1.0 g, 3.06 mmol) and oxalyl chloride (0.6 ml) in ether (10 ml) and DMF (2 drops). The acid chloride is then reacted with the sodium salt of ethyl acetoacetate (0.084 g of sodium and 0.480 g of ethyl acetoacetate) to give ethyl (R)-2-acetyl-4-[4-(4-trifluoromethylphenoxy)phenoxy]-3-oxopentanoate (XVIII; Q1 is CH, Y is hydrogen, Z is trifluoromethyl and R3 is ethyl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04522647 |
| Source dataset | uspto-grants-1985_06 |
| ORD ID | ord-cbccc972f0b44760bfa9659eebcb3db4 |
| Source note | uspto-grants-1985_06 |