HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1248146Generated: October 26, 2026
Tert-Butylamine → alpha-[(Tert-butylamino)methyl]-3,5-dichlorobenzyl Alcohol Hydrochloride
https://huagongshe.com/reaction/1248146
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 2-(3,5-Dichlorophenyl)oxirane | HCID 13488795 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | alpha-[(Tert-butylamino)methyl]-3,5-dichlorobenzyl Alcohol Hydrochloride | HCID 70404526 | — |
Reaction Steps
A solution containing 3.5 g of 3,5-dichlorostyrene oxide in 50 ml of absolute ethanol and 20 ml of t-butylamine is heated gently at reflux for 8 hours and the mixture is evaporated to dryness. The clear yellow syrup is dissolved in 75 ml of ethanol and 25 ml of H2O, and the solution is cooled to 5° C. and acidified with 3N HCl. This solution is evaporated to dryness in vacuo and the residual white solid is recrystallized from acetone to afford 2.81 g, m.p. 218°-221° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04522822 |
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| Source dataset | uspto-grants-1985_06 |
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| ORD ID | ord-ddd7d1ba6a6b40dfb0a588d7db3b9cbd |
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| Source note | uspto-grants-1985_06 |
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