Methyl iodide → HCID 13472771, compound

Participants

Reaction Conditions

Reaction Steps

The organic halide, methyl iodide (5 mL), was added to a solution of 4,5-dimethoxy-1,7,8,12b-tetrahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline (3.0 g, 10 mmol; described in example 2) in acetone (75 mL). The mixture was heated at reflux (reflux time=1 hr.), cooled to 0° C. and diluted with diethyl ether. The solid (isoquinolinium salt) was collected and dried under vacuum to give 4,5-dimethoxy-2-methyl-1,7,8,12b-tetrahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinolinium iodide, mp 179°-182° C.

Provenance & Evidence