Diethyl Ether → HCID 13472775, compound

Participants

Reaction Steps

Methyl iodide (20 mL) was added to a solution of 5,6-dimethoxy-1,7,8,12b-tetrahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline (8.7 g, 29 mmol, described in example 2) in acetone (150 mL). The mixture was heated at reflux (reflux time=30 min.). After cooling, diethyl ether was added to the mixture. The solid material in the mixture was collected and dried to give 5,6-dimethoxy-2-methyl-1,7,8,12b-tetrahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinolinium iodide (11.8 g), a sample of which had mp 195°-210° C. after successive recrystallizations from acetone and methanol-diethyl ether.

Provenance & Evidence