Methyl iodide → HCID 13472775, compound

Participants

Reaction Steps

By following serially the procedure of step (a) of example 5 and the procedure of example 6, and selecting 5,6-dimethoxy-1,7,8,12b-tetrahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline (described in example 2) as the starting material of formula II, methyl iodide as the organohalide and ethyl magnesium bromide as the Grignard reagent, (3,12b-trans)-3-ethyl-5,6-dimethoxy-2-methyl-1,2,3,7,8,12b-hexahydrobenzo[6,7]cyclohepta]1,2,3-de]isoquinoline, mp 92°-94° C., was obtained via 5,6-dimethoxy-2-methyl-1,7,8,12b-tetrahydrobenzo[6,7]cyclohepta[1,2,3-de]-isoquinolinium iodide, mp 195°-210° C., NMR (DMSO-d6) δ 3.83 (s, 3H), 3.88 (s, 3H), 3.97 (s, 3H), 4.42 (m, 2H), 5.18 (m, 1H), 7.10 (m, 4H), 7.38 (s, 1H), 9.17 (s, 1H).

Provenance & Evidence