Methyl iodide → HCID 13472775, compound

Participants

Reaction Steps

By following serially the procedure of step (a) of example 5 and the procedure of example 6 and selecting 5,6-dimethoxy-1,7,8,12b-tetrahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline as the starting material of formula II, methyl iodide as the organohalide and phenylmethyl magnesium chloride as the Grignard reagent, (3,12b-trans)-5,6-dimethoxy-2-methyl-3-(phenylmethyl)-1,2,3,7,8,12b-hexahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline, mp 154°-156° C., NMR (CDCl3) δ2.4 (s, 3H), 3.77 & 3.85 (2s, 6H), 6.5 (s, 1H), 7.2 (m, 9H), was obtained via 5,6-dimethoxy-2-methyl-1,7,8,12b-tetrahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinolinium iodide, mp 195°-210° C. (dec), NMR (DMSO-d6) δ 3.83 (s, 3H), 3.88 (s, 3H), 3.97 (s, 3H), 4.42 (m, 2H), 5.18 (m, 1H), 7.10 (m, 4H), 7.38 (s, 1H), 9.17 (s, 1H).

Provenance & Evidence