Benzyl Bromide → HCID 20278981, compound

Participants

Reaction Steps

By following serially the procedure of step (a) of example 5 and the procedure of example 6 and selecting 5,6-dimethoxy-1,7,8,12b-tetrahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline as the starting material of formula II, benzyl bromide as the organohalide and methyl magnesium iodide as the Grignard reagent, (3,12b-trans)-5,6-dimethoxy-3-methyl-2-(phenylmethyl)-1,2,3,7,8,12b-hexahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline, mp 160°-162° C., NMR (CDCl3) δ6.5 (s, 1H), 7.25 (m, 9H), was obtained via 5,6-dimethoxy-2-phenylmethyl-1,7,8,12b-tetrahydrobenzo-[6,7]cyclohepta[1,2,3-de]isoquinolinium bromide, mp 196° C. (dec), NMR (DMSO-d6) δ 3.85 & 3.95 (2s, 6H), 5.15 (m, 1H), 5.32 & 5.62 (2d, J=13.7 Hz, 2H), 6.1-7.8 (m, 10H), 9.6 (s, 1H).

Provenance & Evidence