Diethyl (ethoxymethylene)malonate → HCID 13312969, compound

Participants

Reaction Steps

2-amino-5-(2-methyl-morpholino)-1,3,4-thiadiazole (10 g) was reacted with diethyl ethoxymethylene-malonate (11.3 g) at 120° C. for 30 minutes: after cooling the reaction mixture was crystallized from isopropyl ether to give diethyl N-[5-(2-methyl-morpholino)-1,3,4-thiadiazol-2-yl]-aminomethylene-malonate, m.p. 89°-91° C. (16.4 g), which was treated with polyphosphoric acid (6.9 g) and POCl3 (27.15 g) under stirring at 120° C. for 30 minutes.

Provenance & Evidence