Butyl bromide → HCID 20279073, compound

Participants

Reaction Steps

Diethyl(cyclohexylmethyl)malonate (5.12 g) was added to a solution of sodium ethoxide (from 0.5 g of sodium in ethanol (50 ml)) and the mixture warmed to 60° C. n-Butyl bromide (4.0 g) was then added and the mixture heated overnight under reflux, and the crude product isolated as in Part A above. Chromatography on silica gel eluting with 0-7.5% ethyl acetate in hexane gave pure diethyl 2-n-butyl-2-(cyclohexylmethyl)malonate.

Provenance & Evidence