反应详情

To a stirred and cooled mixture of 25 parts of 2-aminoethanol and 135 parts of methylbenzene is added dropwise a solution of 29 parts of 4-fluoro-2-nitrobenzoyl chloride in methylbenzene. Upon completion, stirring is continued for 30 minutes at room temperature. The precipitated product is filtered off, taken up in water and extracted with 4-methyl-2-pentanone. The extract is dried, filtered and evaporated, yielding 28 parts (64%) of 4-fluoro-N-(2-hydroxyethyl)-2-nitrobenzamide as a residue.

1. temperaturecooled
2. stirringUpon completion, stirring
3. filtrationThe precipitated product is filtered off
4. extractionextracted with 4-methyl-2-pentanone
5. customThe extract is dried
6. filtrationfiltered
7. customevaporated