HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → N-(2-chloroethyl)-4-fluoro-2-nitrobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-fluoro-N-(2-hydroxyethyl)-2-nitrobenzamide | HCID 20278966 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N-(2-chloroethyl)-4-fluoro-2-nitrobenzamide | HCID 20278955 | 83% |
Reaction Steps
A mixture of 28 parts of 4-fluoro-N-(2-hydroxyethyl)-2-nitrobenzamide, 40 parts of thionyl chloride and 150 parts of trichloromethane is stirred and refluxed for 2 hours. After cooling, the precipitated product is filtered off and dried, yielding 24.5 parts (83%) of N-(2-chloroethyl)-4-fluoro-2-nitrobenzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04522945 |
| Source dataset | uspto-grants-1985_06 |
| ORD ID | ord-5813073b5e9e4eaaafe7146d40141dc4 |
| Source note | uspto-grants-1985_06 |