HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → Methyl 2-azido-3-(benzylsulfanyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Methyl 3-(benzylsulfanyl)-2-chloropropanoate | HCID 14189833 | — |
| Catalyst | Trioctylmethylammonium chloride | HCID 21218 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 2-azido-3-(benzylsulfanyl)propanoate | HCID 14189838 | 99% |
Reaction Steps
15.0 grams (61.3 mmoles) of the 2-chloro-3-benzylmercapto-propionic acid methyl ester produced in Example 3 were stirred with 5.98 grams (92.0 mmoles) of sodium azide and 1.5 grams of Aliquat 336 in 30 ml of water for 7 hours at 45° C. After working up according to Example 2 there were obtained 15.2 grams (99% of theory) of 2-azido-3-benzylmercapto-propionic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04523012 |
| Source dataset | uspto-grants-1985_06 |
| ORD ID | ord-cab2bd96767a48038684fa5ac44bdcce |
| Source note | uspto-grants-1985_06 |