HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → S-benzyl-(L)-cysteine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-azido-3-(benzylsulfanyl)propanoate | HCID 14189838 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Rhenium | HCID 23947 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | S-benzyl-(L)-cysteine methyl ester | HCID 450313 | 73.6% |
Reaction Steps
0.91 gram (3.62 mmoles) of the 2-azido-3-benzylmercapto-propionic acid methyl ester obtained in Example 4 was dissolved in 8 ml of methanol, treated with 0.27 gram (7.41 mmoles) of HCl gas and there was added 1 mole % of rhenium VII sulfide, based on the amount of azido compound employed. Hydrogen was led into this vigorously stirred reaction mixture for 45 hours. The working up according to Example 19 gave 0.60 gram (63% of theory) of S-benzyl-cysteine methyl ester.HCl having a melting point of 84° to 87° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04523012 |
| Source dataset | uspto-grants-1985_06 |
| ORD ID | ord-f0a5c5ce686542189b28a8f6e09c99dc |
| Source note | uspto-grants-1985_06 |