Acetic Acid → HCID 20279315, compound

Participants

Reaction Steps

To a mixture of 7.7 g (ca. 37 mmole) of the title product of Example 18, 2.1 ml of acetic acid, 30 ml of 37% formaldehyde, and 50 ml of acetonitrile was added 2.3 g (37 mmole) of sodium cyanoborohydride. After the amino compound had been consumed, aqueous sodium hydroxide was added and the mixture extracted with diethyl ether. The organic phase was washed with water, dried over magnesium sulfate, filtered, and concentrated in vacuo. The residue was chromatographed on silica gel using ethyl acetate-hexane as eluent, giving the title compound (4.2 g) as an oil. The compound was used in subsequent reeactions without further purification.

Provenance & Evidence